Job Details

Associate Scientist - Protein Science Pipeline

OXFORDSHIRE

Immunocore is an innovative and dynamic biotechnology company developing a unique platform of T Cell antigen receptor-based therapeutics, called ImmTAXs, as a novel class of treatments for cancer, infectious and autoimmune diseases. Immunocore has a well- established pipeline of wholly owned programmes, of world leading science and strong IP position, which has led to discovery collaborations with Genentech, GlaxoSmithKline, Medimmune as well as a co-discovery & co-development partnership with Lilly, and recent investment from the Bill & Melinda Gates Foundation.

The Research department is now seeking an Associate Scientist to join the Protein Science Pipeline team. As a part of the team you will be responsible for the engineering of ImmTAX molecules in the pipeline from the initial identification and characterization of wt TCRs through the production of affinity enhanced, potent and specific molecules.  

KEY RESPONSIBILITIES

  • Running pre-established experimental investigations, with guidance from line managers, a mentor or colleagues
  • Designing and producing DNA constructs for TCR and ImmTAX expression
  • TCR and ImmTAX expression in bacterial and mammalian cells and purification via affinity tags or using ion-exchange and size exclusion chromatography (AKTA system)
  • Analysing TCR and ImmTAX binding affinity, kinetics and specificity using SPR (BIAcore) method
  • Identifying specific TCRs from TCR-phage libraries through series of selection rounds
  • Analysing and reporting experimental results verbally and in writing
  • Maintaining and increasing technical knowledge in relevant fields through self-study, observation, attending relevant conferences and training courses
  • Maintaining accurate records of all work by following Company procedures

EXPERIENCE AND KNOWLEDGE

  • Operated in a bench- based laboratory environment with competence in the safe use of general laboratory equipment
  • Recorded results and information in a concise, accurate and timely way as part of studies or in a work environment
  • Worked and contributed actively in a diverse team environment
  • Experience in the areas of protein biochemistry:
    • Protein expression in bacterial and/or mammalian system
    • Protein purification using affinity tags, ion exchange and size exclusion chromatography methods
  • Experience in the areas of molecular biology:
    • Molecular cloning of DNA constructs (Primer design, PCR and gel electrophoresis)
  • Experience in cell biology techniques is desirable:
    • Maintenance of different cell lines for experimental use

EDUCATION & QUALIFICATIONS

  • BSc or MSc. in protein engineering, biochemistry, molecular biology or related discipline 
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